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Skyler White repeatedly asked Walt to tell his mother about his cancer. ("Cancer Man")
After growing suspicious about Walt's behavior, Skyler called his mother to see if he'd been getting money to pay for his treatment from her and found out that Walt had not told her that he had cancer, nor had he been to visit her. ("ABQ")
While talking about his father, Walter said how his mother was terrified that he might suffer from Huntington's disease too and got him tested. When his father was dying, Walt's mother would take him to the hospital to visit and try to keep a positive attitude. After his father's death, his mother would continue to tell Walt many stories about him. ("Salud")