- "Why are you like this? Why?!"
- ―Mrs. Pinkman to her son Jessie after she slaps him
She firmly opposes Jesse's involvement in illicit drugs. When Jesse comes crashing into their backyard, she allows him to stay on the condition that he stays clean and goes to meetings, yet she still worries that he might be a bad influence on their younger son, Jake. Mr. and Mrs. Pinkman kick Jesse out of the house when they find marijuana in the house and assume it's his (in fact, it's Jake's) ("Cancer Man").
Mrs. Pinkman is visited by Hank Schrader when he's searching for Jesse in relation to Walter White's disappearance. Once again she expresses her disapproval of Jesse's lifestyle. All she reveals is that Jesse's '89 Monte Carlo is a lowrider, which leads Hank to correctly infer that it also has LoJack ("Grilled").
Hank's visit makes her suspicious, so she enters Jesse's House and finds the meth lab that Jesse and Walt had temporarily setup in the basement. Since Mr. and Mrs. Pinkman actually own the house and could be held liable for crimes committed inside, they force their son out ("Down").
Mr. and Mrs. Pinkman spend nearly $400,000 renovating the house in preparation to sell it. Jesse is able to buy it from them anonymously through Saul Goodman at less than half price because they attempted to sell it without disclosing that there was a meth lab in the basement. Jesse then shows up and, when asked by his mother where he is going, states in quiet triumph: "Inside. I bought the place.". ("Caballo Sin Nombre").
Mrs. Pinkman is not seen for the rest of the series, though it is likely she has cut off all contact with her son permanently.