After the violent deaths of several of his family members, only Joaquin and his retired grandfather "Tio" remained to carry the Salamanca name. Joaquin worked directly for the cartel boss Don Eladio Vuente as an enforcer alongside Gaff in Mexico. He was present at Don Eladio's estate when the American meth distributor Gustavo Fring (with Mike Ehrmantraut and Jesse Pinkman) was invited to celebrate their partnership. Joaquin and Gaff escorted a blindfolded Gus, Mike, and Jesse to meet with Benicio Fuentes in the cartel's superlab. He stood by while Jesse cooked a batch of Blue Sky meth and observed the process.
Later, while Joaquin was posted elsewhere on the property, Gus succeeded in lethally poisoning Don Eladio, his nine capos, Fuentes, and his bodyguard Miguel; Gaff was garroted nearby by Mike. As the servants and concubines stuffed their pockets and fled the compound, Joaquin surprised the fleeing Mike and Jesse (who were carrying an unconscious Gus to a getaway car) and shot Mike in the gut. Jesse returned fire, shooting rapidly, and hit Joaquin in the leg before shooting him several more times in the chest. ("Salud").
Gus, safely back in America a short time later, continued his habitual torment of Joaquin's grandfather Hector "Tio" Salamanca (in return for Hector's murder of Gus's friend, Max Arciniega). Gus now described the collapse of Tio's former cartel: as Tio sat, mute, Gus triumphantly dangled Don Eladio's extravagant bad eye necklace in front of his eyes and named seven of the nine dead capos (Dons Paco, Cesar, Renaldo, Artuno, Cisco, Luis and Escalada). He then described Joaquin's death and introduced him to his grandson's killer, Jesse. As Hector started crying in anger, Gus concluded with a flourish, stating gravely that the Salamanca name will now die with Hector ("Crawl Space").