Cisco was present at Don Eladio's party at his mansion in Mexico along with Eladio, Gustavo Fring, Mike Ehrmantraut, Jesse Pinkman, Benicio Fuentes, Gaff, Miguel, and several other capos. There, he joined in on the celebrations by drinking Gus's Zafiro Añejo tequila and mingling with the invited girls.
However, the tequila was poisoned, and Cisco died not long after drinking it along with Eladio, Fuentes, Miguel, and the other capos. ("Salud")
- Although Cisco certainly appeared onscreen during the party, it's unclear exactly which capo he was.